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Indeed, a daily dose of liraglutide, a GLP-1 agonist, to obese patients led to substantial and sustained weight loss (54)

Ipamorelin was developed specifically to address this selectivity problem

Safety In l-ARG and placebo groups, no significant changes were detected from T0 to T1, regarding clinical and biochemical parameters, except for HDL cholesterol levels, which were significantly increased in l-ARG group ( p = 0.001) and decreased in placebo group ( p = 0.0001)